Sickle Cell Anemia

HBB: The Gene Associated with Sickle Cell Anemia Approximate component fixing is based on Chromosome 11 map from NCBI Entrez constitute Viewer. authoritative Gene Symbol: HBB Name of Gene intersection point: hemo hematohiston, of import Alternate Name of Gene Product: grievous globin venue: 11p15.5 - The HBB agent is base in percentage 15.5 on the con (p) arm of human chromosome 11. Gene bodily building: The normal allelomorphic variant for this gene is 1600 base pairs (bp) huge and contains three exons. template RNA: The intron-free messenger RNA transcript for the HBB gene is 626 base pairs long. See the NCBI eon translate NM_000518 to access the mRNA sequence data. Coding era (CDS): 444 base pairs within the mRNA code for the aminic group caustic sequence of the genes protein product. Protein Size: The HBB protein is 146 amino acids long and has a molecular(a) weight of 15,867 Da. See the annotated HBB protein sequence recor d in Swiss-Prot. Protein belong: Hemoglobin sh rubys, which reside in rosy-cheeked blood cellph unmatchables, atomic number 18 responsible for carrying type O from the lungs to various parts of the body for mapping in respiration. The HBB gene codes for one of the ii types of polypeptide chains found in grownup hemoglobin. Normal adult hemoglobin is a tetrameric protein consisting of two of import chains and two of import chains.

HBB codes for the beta chain, which is often referred to as beta globin. Mutant beta globin is responsible for the sickling of red blood cells seen in sickle cell anemia. Protein Struc ture The structure of normal deoxy hemog! lobin is shown in ascertain 1. The four antique clusters ar noncovalently bonded hematin groups. Each heme serves as a contact site for binding one molecule of oxygen. The two atomic number 79 spheres near the top of the molecule are orthophosphate groups. The green and blue chains are alpha chains, and the gold and aqua chains are beta chains. The red lash highlights the general region of two beta chains where the ordinal glutamic acid residue is located. A inheritable variant associated with this amino acid...If you want to get a all-inclusive essay, order it on our website: OrderCustomPaper.com

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